Nanotechnology: a New Approach for Ocular Drug Delivery System
نویسندگان
چکیده
In current drug delivery scenario, despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. In ocular drug delivery system, ocular infections are treated by various topical drug applications in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability due to minimum ocular residence time, because of various anatomical and pathophysiological barriers prevailing in the eye. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings and applications of various nanoparticulate systems like nanosuspensions and nanoparticles in the field of ocular drug delivery and review also summarizes the various method of preparation of nanocarriers for ophthalmic drug delivery.
منابع مشابه
Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug delivery
Objective(s): The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin A. Material and Methods: Formulations were designed based on full factorial design. A high pressure homogenization technique was used to produce nanosuspensions. Fifteen formulations were prepared by the use of different combinations of surfa...
متن کاملNanotechnology: A new approach in pharmaceutics
Nanotechnology has changed our lives dramatically and influenced every sector of the research, engineering and also business community. Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles, that measure in nanometer. In other words, nanotechnology is the art of characterizing, manipulating and organizing matter systemically, at the nanometer scale, which h...
متن کاملNanotechnology: A new approach in pharmaceutics
Nanotechnology has changed our lives dramatically and influenced every sector of the research, engineering and also business community. Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles, that measure in nanometer. In other words, nanotechnology is the art of characterizing, manipulating and organizing matter systemically, at the nanometer scale, which h...
متن کاملFormulation of Tolmetin Ocuserts As Carriers for Ocular Drug Delivery System
Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...
متن کاملمروری بر دستاوردهای اخیر نانوتکنولوژی در رفع چالشهای دارورسانی موضعی به بخشهای قدامی و خلفی چشم: مقاله مروری
Eyes and the vision system allow the human being to receive information from the environment to the extent that 90% of the man’s information is acquired through observation, thus health and correct function of this organ have always been important. Diseases threatening vision such as Acute Macular Degeneration and Diabetic Retinopathy deprive millions of people of seeing every year while acce...
متن کامل